Ghent is located on the intersection of two major European motorways: the E17 and the E40. From the E17 you take the ‘Gent Centrum’ turnoff. On the E40, from the motorway intersection in Zwijnaarde you first follow ‘Antwerpen’ (E17) and then take the ‘Gent Centrum’ turnoff.
Ghent by coach
This publication tells you how and where you can drop off your passengers and park.